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Massachusetts Cannabis Control Commission announces potential adverse health effects related to marijuana-infused products containing Corydalis



The Massachusetts Cannabis Control Commission has announced that there are potential adverse health effects allegedly related to the consumption of marijuana-infused products containing Corydalis rhizome extract, a.k.a. Corydalis yanhusuo.

The Commission has become aware of a recent notification from the Colorado Department of Revenue’s Marijuana Enforcement Division indicating that consumption of an MIP in Colorado marketed as 1906 Midnight Drops may have led to certain adverse health issues, including potential liver injury. A similar report was recently received from a Massachusetts medical provider concerning 1906 Midnight Drops, an MIP available for sale in the Commonwealth and manufactured using the ingredient Corydalis. Because Corydalis has been associated with an elevated risk of liver injury, a.k.a., hepotoxicity, and may pose a risk to the public health, safety, and welfare, the Commission is currently investigating this ingredient, including one of its alkaloids, tetrahydropalmatine (THP). At this time, the Commission is not exercising its authority to issue a product recall or limit the sale of specific products or product categories. Instead, this bulletin is intended to inform the public of its active and ongoing investigation into this ingredient.

The Commission’s regulations require all MIPs to have a product label listing its ingredients. Any patient or consumer who experiences adverse health effects from consuming 1906 Midnight Drops, or any marijuana product containing Corydalis, should seek immediate medical attention and may report the event to the Commission by calling (774) 415-0200 or via email at



  1. Ken Masson

    August 14, 2022 at 9:00 am

    What I’m not clear on is this a product that’s being distributed on the streets or is this something legally available in dispensaries and manufactured in this state?

  2. David Raynes

    August 14, 2022 at 12:40 pm

    But Cannabis itself, cannabinoids in general, are being associated with birth defects and cancers, particularly testicular cancers. The rate of birth defects in Colorado said to be 4 times the US background rate. Autism, Atrial Septal Defect, missing or small ears, limb defects, Gstroschisis etc

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